OSU-03012

Ligand id: 8005

Name: OSU-03012

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 72.42
Molecular weight 460.15
XLogP 5.68
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. Hanada M, Feng J, Hemmings BA. (2004)
Structure, regulation and function of PKB/AKT--a major therapeutic target.
Biochim. Biophys. Acta, 1697 (1-2): 3-16. [PMID:15023346]
2. Shiojima I, Walsh K. (2002)
Role of Akt signaling in vascular homeostasis and angiogenesis.
Circ. Res., 90 (12): 1243-50. [PMID:12089061]
3. Zhu J, Huang JW, Tseng PH, Yang YT, Fowble J, Shiau CW, Shaw YJ, Kulp SK, Chen CS. (2004)
From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors.
Cancer Res., 64 (12): 4309-18. [PMID:15205346]