CCL19   Click here for help

GtoPdb Ligand ID: 810

Synonyms: β-chemokine exodus-3 | ck β-11 | ckβ11 | MIP-3β
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: CCL19 is a CC family chemokine.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Barnea G, Strapps W, Herrada G, Berman Y, Ong J, Kloss B, Axel R, Lee KJ. (2008)
The genetic design of signaling cascades to record receptor activation.
Proc Natl Acad Sci USA, 105 (1): 64-9. [PMID:18165312]
2. Leick M, Catusse J, Follo M, Nibbs RJ, Hartmann TN, Veelken H, Burger M. (2010)
CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B.
Immunology, 129 (4): 536-46. [PMID:20002784]
3. Ott TR, Lio FM, Olshefski D, Liu XJ, Ling N, Struthers RS. (2006)
The N-terminal domain of CCL21 reconstitutes high affinity binding, G protein activation, and chemotactic activity, to the C-terminal domain of CCL19.
Biochem Biophys Res Commun, 348 (3): 1089-93. [PMID:16904643]
4. Sullivan SK, McGrath DA, Grigoriadis D, Bacon KB. (1999)
Pharmacological and signaling analysis of human chemokine receptor CCR-7 stably expressed in HEK-293 cells: high-affinity binding of recombinant ligands MIP-3beta and SLC stimulates multiple signaling cascades.
Biochem Biophys Res Commun, 263: 685-690. [PMID:10512740]
5. Watts AO, Verkaar F, van der Lee MM, Timmerman CA, Kuijer M, van Offenbeek J, van Lith LH, Smit MJ, Leurs R, Zaman GJ et al.. (2013)
β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR.
J Biol Chem, 288 (10): 7169-81. [PMID:23341447]
6. Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. (1998)
Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.
J Biol Chem, 273 (29): 18288-91. [PMID:9660793]
7. Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O. (1997)
Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7.
J Biol Chem, 272 (21): 13803-9. [PMID:9153236]
8. Yoshida R, Nagira M, Kitaura M, Imagawa N, Imai T, Yoshie O. (1998)
Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7.
J Biol Chem, 273: 7118-7122. [PMID:9507024]