CCL19   

GtoPdb Ligand ID: 810

Synonyms: β-chemokine exodus-3 | ck β-11 | ckβ11 | MIP-3β
Comment: CCL19 is a CC family chemokine.
Species: Human
Bioactivity Comments
The receptor for CCL19 is CCR7. CCL19 is maily expressed in thymus and lymph nodes, and functions in trafficking of T cells in the thymus and migration of T and B cells to secondary lymphoid organs.
Natural/Endogenous Targets
Target
ACKR4
CCR7
CCRL2
CXCR3
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CCR7 Hs Agonist Agonist 10.0 pKd - 4
pKd 10.0 (Kd 1x10-10 M) [4]
ACKR4 Hs Agonist Agonist 8.4 pKi - 5
pKi 8.4 [5]
CXCR3 Hs Agonist Full agonist 5.9 pKi - 6
pKi 5.9 [6]
ACKR4 Hs Agonist Agonist 8.5 – 9.1 pEC50 - 5
pEC50 8.5 – 9.1 [5]
CCR7 Hs Agonist Agonist 7.7 – 9.0 pIC50 - 3,7-8
pIC50 7.7 – 9.0 [3,7-8]
CCRL2 Hs Agonist Unknown 7.4 pIC50 - 2
pIC50 7.4 [2]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference