Ligand id: 8317

Name: azeliragon

Structure and Physico-chemical Properties

2D Structure
Click here for structure editor
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 14
Topological polar surface area 39
Molecular weight 531.27
XLogP 8.8
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

1. Burstein AH, Grimes I, Galasko DR, Aisen PS, Sabbagh M, Mjalli AM. (2014)
Effect of TTP488 in patients with mild to moderate Alzheimer's disease.
BMC Neurol, 14: 12. [PMID:24423155]
2. Deane R, Du Yan S, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J et al.. (2003)
RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain.
Nat. Med., 9 (7): 907-13. [PMID:12808450]
3. Mjalli A, Andrews R, Shen J, Rothlein R. (2005)
Rage antagonists as agents to reverse amyloidosis and diseases associated therewith.
Patent number: US20050026811 A1. Assignee: Mjalli A, Andrews R, Shen J, Rothlein R. Priority date: 20/05/2003. Publication date: 03/02/2005.
4. Saito S, Ihara M. (2014)
New therapeutic approaches for Alzheimer's disease and cerebral amyloid angiopathy.
Front Aging Neurosci, 6: 290. [PMID:25368578]
5. TransTech Pharma. 
Azeliragon (TTP488).
Accessed on 15/04/2015. Modified on 15/04/2015.,