ZD-7155   Click here for help

GtoPdb Ligand ID: 8324

Synonyms: ZD 7155 | ZD7155
PDB Ligand
Compound class: Synthetic organic
Comment: ZD-7155 is an orally active antagonist of the angiotensin II type 1 receptor. It is more potent and longer-acting than the prototype AT1 antagonist, losartan (in rats) [1].
ZD-7155 has been co-crystalised with a modified human AT1 receptor with PDB structure ID 4YAY [3].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 87.66
Molecular weight 438.22
XLogP 5.08
No. Lipinski's rules broken 1
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Canonical SMILES CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2
Isomeric SMILES CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2
InChI InChI=1S/C26H26N6O/c1-3-19-15-24-22(23(4-2)27-19)13-14-25(33)32(24)16-17-9-11-18(12-10-17)20-7-5-6-8-21(20)26-28-30-31-29-26/h5-12,15H,3-4,13-14,16H2,1-2H3,(H,28,29,30,31)
1. Junggren IL, Zhao X, Sun X, Hedner T. (1996)
Comparative cardiovascular effects of the angiotensin II type 1 receptor antagonists ZD 7155 and losartan in the rat.
J Pharm Pharmacol, 48 (8): 829-33. [PMID:8887734]
2. Wexler RR, Greenlee WJ, Irvin JD, Goldberg MR, Prendergast K, Smith RD, Timmermans PB. (1996)
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.
J Med Chem, 39 (3): 625-56. [PMID:8576904]
3. Zhang H, Unal H, Gati C, Han GW, Liu W, Zatsepin NA, James D, Wang D, Nelson G, Weierstall U et al.. (2015)
Structure of the Angiotensin receptor revealed by serial femtosecond crystallography.
Cell, 161 (4): 833-44. [PMID:25913193]