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Synonyms: compound 45 [PMID 25856009] | GSK602
Compound class: Synthetic organic
Comment: This structure was drawn from the Structural Genomics Consortium's chemical probe page for I-BRD9 . I-BRD9 is the first selective tool compound which will be useful in resolving the biological function of bromodomain containing 9 (BRD9) . This is a compound from the Structural Genomics Consortium's (SGC) Epigenetics Probes Collection.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Structural Genomics Consortium.
I-BRD9 – a chemical probe for BRD9.
Accessed on 02/06/2015. Modified on 02/06/2015. thesgc.org, http://www.thesgc.org/chemical-probes/I-BRD9
2. Theodoulou NH, Bamborough P, Bannister AJ, Becher I, Bit RA, Che KH, Chung CW, Dittmann A, Drewes G, Drewry DH et al.. (2016)
Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition.
J. Med. Chem., 59 (4): 1425-39. [PMID:25856009]