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Synonyms: AZD 5438 | AZD-5438
Compound class: Synthetic organic
Comment: AZD5438 is a potent oral inhibitor of cyclin dependent kinases (CDKs) 1, 2 and 9 .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Byth KF, Thomas A, Hughes G, Forder C, McGregor A, Geh C, Oakes S, Green C, Walker M, Newcombe N et al.. (2009)
AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts.
Mol Cancer Ther, 8 (7): 1856-66. [PMID:19509270]
2. Malumbres M, Barbacid M. (2005)
Mammalian cyclin-dependent kinases.
Trends Biochem Sci, 30 (11): 630-41. [PMID:16236519]
3. Ortega S, Malumbres M, Barbacid M. (2002)
Cyclin D-dependent kinases, INK4 inhibitors and cancer.
Biochim Biophys Acta, 1602 (1): 73-87. [PMID:11960696]
4. Santamaria D, Ortega S. (2006)
Cyclins and CDKS in development and cancer: lessons from genetically modified mice.
Front Biosci, 11: 1164-88. [PMID:16146805]
5. Shapiro GI. (2006)
Cyclin-dependent kinase pathways as targets for cancer treatment.
J Clin Oncol, 24 (11): 1770-83. [PMID:16603719]