CGS-27023A   

GtoPdb Ligand ID: 8846

Synonyms: CGS 27023A | CGS27023A | MMI270
Compound class: Synthetic organic
Comment: CGS-27023A is reported as a potent pan-inhibitor of matrix metalloproteinases [2].
Note that CGS-27023A imay be used experimentally as the hydrochloride salt (PubChem CID 9888897).
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 117.21
Molecular weight 393.14
XLogP 1.4
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES ONC(=O)C(N(S(=O)(=O)c1ccc(cc1)OC)Cc1cccnc1)C(C)C
Isomeric SMILES ONC(=O)[C@H](N(S(=O)(=O)c1ccc(cc1)OC)Cc1cccnc1)C(C)C
InChI InChI=1S/C18H23N3O5S/c1-13(2)17(18(22)20-23)21(12-14-5-4-10-19-11-14)27(24,25)16-8-6-15(26-3)7-9-16/h4-11,13,17,23H,12H2,1-3H3,(H,20,22)/t17-/m1/s1
InChI Key BSIZUMJRKYHEBR-QGZVFWFLSA-N
References
1. Levitt NC, Eskens FA, O'Byrne KJ, Propper DJ, Denis LJ, Owen SJ, Choi L, Foekens JA, Wilner S, Wood JM et al.. (2001)
Phase I and pharmacological study of the oral matrix metalloproteinase inhibitor, MMI270 (CGS27023A), in patients with advanced solid cancer.
Clin. Cancer Res., 7 (7): 1912-22. [PMID:11448904]
2. Nuti E, Casalini F, Santamaria S, Gabelloni P, Bendinelli S, Da Pozzo E, Costa B, Marinelli L, La Pietra V, Novellino E et al.. (2011)
Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors.
Eur J Med Chem, 46 (7): 2617-29. [PMID:21514700]