Ligand id: 8948

Name: AZD5069

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 10
Topological polar surface area 158.56
Molecular weight 476.1
XLogP 1.73
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Cheshire DR, Cox RJ, Meghani P, Stonehouse JP. (2010)
Pyrimidine sulphonamide derivatives as chemokine receptor modulators.
Patent number: US7838675 B2. Assignee: Astrazeneca Ab.. Priority date: 28/08/2004. Publication date: 23/11/2010.
2. De Soyza A, Pavord I, Elborn JS, Smith D, Wray H, Puu M, Larsson B, Stockley R. (2015)
A randomised, placebo-controlled study of the CXCR2 antagonist AZD5069 in bronchiectasis.
Eur. Respir. J., 46 (4): 1021-32. [PMID:26341987]
3. Nicholls DJ, Wiley K, Dainty I, MacIntosh F, Phillips C, Gaw A, MĂ„rdh CK. (2015)
Pharmacological characterization of AZD5069, a slowly reversible CXC chemokine receptor 2 antagonist.
J. Pharmacol. Exp. Ther., 353 (2): 340-50. [PMID:25736418]