Synonyms: BIA 9-1067 | compound 37d [PMID: 20334432] [2] | Ongentys® | Ontilyv®
opicapone is an approved drug (EMA & UK (2016), FDA 2020)
Compound class:
Synthetic organic
Comment: Opicapone is a novel third generation, long-acting catechol-O-methyltransferase (COMT) inhibitor [2]. This mechanism reduces peripheral degradation of levodopa as used as Parkinson's disease therapy.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Ferreira JJ, Lees A, Rocha JF, Poewe W, Rascol O, Soares-da-Silva P, Bi-Park 1 investigators. (2016)
Opicapone as an adjunct to levodopa in patients with Parkinson's disease and end-of-dose motor fluctuations: a randomised, double-blind, controlled trial. Lancet Neurol, 15 (2): 154-165. [PMID:26725544] |
2. Kiss LE, Ferreira HS, Torrão L, Bonifácio MJ, Palma PN, Soares-da-Silva P, Learmonth DA. (2010)
Discovery of a long-acting, peripherally selective inhibitor of catechol-O-methyltransferase. J Med Chem, 53 (8): 3396-411. [PMID:20334432] |
3. Lanier M, Ambrus G, Cole DC, Davenport R, Ellery J, Fosbeary R, Jennings AJ, Kadotani A, Kamada Y, Kamran R et al.. (2014)
A fragment-based approach to identifying S-adenosyl-l-methionine -competitive inhibitors of catechol O-methyl transferase (COMT). J Med Chem, 57 (12): 5459-63. [PMID:24847974] |