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Synonyms: SC 22716
Compound class: Synthetic organic
Comment: SC-22716 is an experimental leukotriene A4 hydrolase inhibitor. It was the primary lead for the SAR study reported in . SC-22716 acts as a potent, competitive and reversible inhibitor of the hydrolase and peptidase activities of human leukotriene A4 hydrolase.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Penning TD, Chandrakumar NS, Chen BB, Chen HY, Desai BN, Djuric SW, Docter SH, Gasiecki AF, Haack RA, Miyashiro JM et al.. (2000)
Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase.
J Med Chem, 43 (4): 721-35. [PMID:10691697]