bihelical apoA-I mimetic peptide 5A

Ligand id: 9183

Name: bihelical apoA-I mimetic peptide 5A

Structure and Physico-chemical Properties

2D Structure
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1. Nowacki TM, Remaley AT, Bettenworth D, Eisenblätter M, Vowinkel T, Becker F, Vogl T, Roth J, Tietge UJ, Lügering A et al.. (2016)
The 5A apolipoprotein A-I (apoA-I) mimetic peptide ameliorates experimental colitis by regulating monocyte infiltration.
Br. J. Pharmacol., 173 (18): 2780-92. [PMID:27425846]
2. Remaley AT et al.. (2012)
Method of treating or inhibiting inflammation by multi-domain amphipathic helical peptides.
Patent number: US8148323. Assignee: US Government. Priority date: 15/10/2004. Publication date: 03/04/2012.
3. Sethi AA, Stonik JA, Thomas F, Demosky SJ, Amar M, Neufeld E, Brewer HB, Davidson WS, D'Souza W, Sviridov D et al.. (2008)
Asymmetry in the lipid affinity of bihelical amphipathic peptides. A structural determinant for the specificity of ABCA1-dependent cholesterol efflux by peptides.
J. Biol. Chem., 283 (47): 32273-82. [PMID:18805791]
4. Tabet F, Remaley AT, Segaliny AI, Millet J, Yan L, Nakhla S, Barter PJ, Rye KA, Lambert G. (2010)
The 5A apolipoprotein A-I mimetic peptide displays antiinflammatory and antioxidant properties in vivo and in vitro.
Arterioscler. Thromb. Vasc. Biol., 30 (2): 246-52. [PMID:19965776]