Synonyms: CERC-501 | CERC501 | JNJ-67953964 | JNJ67953964 | LY-2456302
Compound class:
Synthetic organic
Comment: LY2456302 is a potent small molecule, centrally-penetrant, selective antagonist of the κ opioid receptor, with potential antidepressant-like effects [2]. It is claimed in patent WO2009094260 [1].
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
|
References |
1. Diaz BN, Mckinzie DL, Mitch CH, Pedregal-Tecero C. (2009)
Kappa selective opioid receptor antagonist. Patent number: WO2009094260. Assignee: Eli Lilly And Company. Priority date: 22/01/2008. Publication date: 30/07/2009. |
2. Rorick-Kehn LM, Witkin JM, Statnick MA, Eberle EL, McKinzie JH, Kahl SD, Forster BM, Wong CJ, Li X, Crile RS et al.. (2014)
LY2456302 is a novel, potent, orally-bioavailable small molecule kappa-selective antagonist with activity in animal models predictive of efficacy in mood and addictive disorders. Neuropharmacology, 77: 131-44. [PMID:24071566] |