urocortin 3   Click here for help

GtoPdb Ligand ID: 928

Synonyms: JNJ-39588146 | JNJ-9588146 | RT-400 | stresscopin
Comment: Urocortin-3 (stresscopin) is a corticotropin-releasing factor type 2 receptor (CRF2R) agonist. In clinical trial for decompensated heart failure it has demonstrated short-term, dose-dependent efficacy in improving cardiac index and systemic vascular resistance.
Species: Human
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1. Dautzenberg FM, Gutknecht E, Van der Linden I, Olivares-Reyes JA, Dürrenberger F, Hauger RL. (2004)
Cell type specific calcium signaling by corticotropin-releasing factor type 1 (CRF1) and 2a (CRF2(a)) receptors: Gq coupling in human embryonic kidney 293 but not SK-N-MC neuroblastoma cells.
Biochem Pharmacol, 68: 1833-1844. [PMID:15450949]
2. Gheorghiade M, Greene SJ, Ponikowski P, Maggioni AP, Korewicki J, Macarie C, Metra M, Grzybowski J, Bubenek-Turconi SI, Radziszewski W et al.. (2013)
Haemodynamic effects, safety, and pharmacokinetics of human stresscopin in heart failure with reduced ejection fraction.
Eur J Heart Fail, 15 (6): 679-89. [PMID:23471413]
3. Lewis K, Li C, Perrin MH, Blount A, Kunitake K, Donaldson C, Vaughan J, Reyes TM, Gulyas J, Fischer W et al.. (2001)
Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor.
Proc Natl Acad Sci USA, 98 (13): 7570-5. [PMID:11416224]