urocortin 3   

GtoPdb Ligand ID: 928

Synonyms: JNJ-39588146 | JNJ-9588146 | RT-400 | stresscopin
Comment: Urocortin-3 (stresscopin) is a corticotropin-releasing factor type 2 receptor (CRF2R) agonist. In clinical trial for decompensated heart failure it has demonstrated short-term, dose-dependent efficacy in improving cardiac index and systemic vascular resistance.
Species: Human
Natural/Endogenous Targets
Target
CRF2 receptor
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CRF2 receptor Hs Agonist Full agonist 7.9 – 8.0 pKd - 1
pKd 7.9 – 8.0 [1]
CRF2 receptor Mm Agonist Full agonist 7.9 pKd - 3
pKd 7.9 [3]
CRF2 receptor Rn Agonist Full agonist 7.7 pKd - 3
pKd 7.7 [3]
Ligand mentioned in the following text fields