urocortin 3   Click here for help

GtoPdb Ligand ID: 928

Synonyms: JNJ-39588146 | JNJ-9588146 | RT-400 | stresscopin
Comment: Urocortin-3 (stresscopin) is a corticotropin-releasing factor type 2 receptor (CRF2R) agonist. In clinical trial for decompensated heart failure it has demonstrated short-term, dose-dependent efficacy in improving cardiac index and systemic vascular resistance.
Species: Human
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Natural/Endogenous Targets
CRF2 receptor
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
CRF2 receptor Ligand is endogenous in the given species Hs Agonist Full agonist 7.9 – 8.0 pKd - 1
pKd 7.9 – 8.0 [1]
CRF2 receptor Mm Agonist Full agonist 7.9 pKd - 3
pKd 7.9 [3]
CRF2 receptor Rn Agonist Full agonist 7.7 pKd - 3
pKd 7.7 [3]
Ligand mentioned in the following text fields