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Synonyms: compound 1b [PMID: 21866885]
Compound class: Synthetic organic
Comment: BU08028 is a novel research compound that provides the pain relief of opiates, without their addictive effects in mouse models of acute pain and cocaine-induced reward [1-2]. Structurally it is a derivative of buprenorphine, with only the addition of an additional methylene group at the C20 substituent. Increasing affinity for the NOP receptor is predicted to reduce the behavioural side-effects associated with buprenorphine.
Note that the compound referred to as 1b in  has a marginally different stereo compared to the same compound (named as BUB8028) in , with identical data provided for 1b and BUB8028 in both articles. Compound 1b resolves to PubChem CID 56664973. We have chosen to link to CID 50922685 as the specified stereochemistry of this is identical to that of buprenorphine.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Cami-Kobeci G, Polgar WE, Khroyan TV, Toll L, Husbands SM. (2011)
Structural determinants of opioid and NOP receptor activity in derivatives of buprenorphine.
J Med Chem, 54 (19): 6531-7. [PMID:21866885]
2. Khroyan TV, Polgar WE, Cami-Kobeci G, Husbands SM, Zaveri NT, Toll L. (2011)
The first universal opioid ligand, (2S)-2-[(5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylpentan-2-ol (BU08028): characterization of the in vitro profile and in vivo behavioral effects in mouse models of acute pain and cocaine-induced reward.
J Pharmacol Exp Ther, 336 (3): 952-61. [PMID:21177476]