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Synonyms: LRRK2-IN1 | LRRK2IN1 
Compound class: Synthetic organic
Comment: LRRK2-IN-1 is a selective inhibitor of the Parkinson's associated kinase LRRK2 (leucine rich repeat kinase 2) . The compound has limited brain penetrance. LRRK2-IN-1 is used as a pharmacological tool to interrogate the function of LRRK2 in Parkinson's disease.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Deng X, Dzamko N, Prescott A, Davies P, Liu Q, Yang Q, Lee JD, Patricelli MP, Nomanbhoy TK, Alessi DR et al.. (2011)
Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.
Nat Chem Biol, 7 (4): 203-5. [PMID:21378983]
2. Kavanagh ME, Doddareddy MR, Kassiou M. (2013)
The development of CNS-active LRRK2 inhibitors using property-directed optimisation.
Bioorg Med Chem Lett, 23 (13): 3690-6. [PMID:23721803]