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Synonyms: Emflaza® | MDL 458
deflazacort is an approved drug (UK (1994), FDA (2017))
Compound class: Synthetic organic
Comment: Deflazacort is a prednisolone derivative glucocorticoid that is used as an anti-inflammatory and immunosuppressant. It is a prodrug that is metabolised to the active form, 21-desacetyl deflazacort (PubChem CID 97547130) .
View more information in the IUPHAR Pharmacology Education Project: deflazacort
1. Griggs RC, Miller JP, Greenberg CR, Fehlings DL, Pestronk A, Mendell JR, Moxley 3rd RT, King W, Kissel JT, Cwik V et al.. (2016)
Efficacy and safety of deflazacort vs prednisone and placebo for Duchenne muscular dystrophy.
Neurology, 87 (20): 2123-2131. [PMID:27566742]
2. Luzzani F, Glässer A. (1981)
Differential binding in vitro to glucocorticoid receptors of deflazacort and prednisolone.
Eur J Pharmacol, 76 (4): 427-30. [PMID:7327211]
3. Möllmann H, Hochhaus G, Rohatagi S, Barth J, Derendorf H. (1995)
Pharmacokinetic/pharmacodynamic evaluation of deflazacort in comparison to methylprednisolone and prednisolone.
Pharm Res, 12 (7): 1096-100. [PMID:7494809]