H2S   Click here for help

GtoPdb Ligand ID: 9532

Synonyms: hydrogen sulfide
Immunopharmacology Ligand
Compound class: Inorganic
Comment: H2S is derived from L-cysteine by the enzymes cystathionine β-synthase, cystathionine γ-lyase, and 3-mercaptopyruvate sulfurtransferase. Like NO, hydrogen sulfide is involved in the relaxation of smooth muscle that causes erection of the penis, presenting possible new therapy opportunities for erectile dysfunction.
Novel H2S-releasing drugs are being developed for anti-inflammatory activity and these are receiving additional attention for chemoprevention of cancers [1].
1. Flannigan KL, Wallace JL. (2015)
Hydrogen sulfide-based anti-inflammatory and chemopreventive therapies: an experimental approach.
Curr Pharm Des, 21 (21): 3012-22. [PMID:26004409]