Ligand id: 9562

Name: PFK15

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 42.85
Molecular weight 260.09
XLogP 2.79
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Clem BF, O'Neal J, Tapolsky G, Clem AL, Imbert-Fernandez Y, Kerr 2nd DA, Klarer AC, Redman R, Miller DM, Trent JO et al.. (2013)
Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer.
Mol. Cancer Ther., 12 (8): 1461-70. [PMID:23674815]
2. Zou Y, Zeng S, Huang M, Qiu Q, Xiao Y, Shi M, Zhan Z, Liang L, Yang X, Xu H. (2017)
Inhibition of 6-phosphofructo-2-kinase suppresses fibroblast-like synoviocytes-mediated synovial inflammation and joint destruction in rheumatoid arthritis.
Br. J. Pharmacol., 174 (9): 893-908. [PMID:28239846]