Ligand id: 9615

Name: ALT-803

Structure and Physico-chemical Properties

2D Structure
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1. Miller JS, Cooley S, Holtan S, Arora M, Ustun C, Jeng E, Wong HC, Verneris MR, Wagner JE, Weisdorf DJ et al.. (2015)
'First-in-human' phase I dose escalation trial of IL-15N72D/IL-15Rα-Fc superagonist complex (ALT-803) demonstrates immune activation with anti-tumor activity in patients with relapsed hematological malignancy.
Blood, 126: 1957 Meeting poster. DOI: 10.1182/blood.V126.23.1957.1957
2. Rhode PR, Egan JO, Xu W, Hong H, Webb GM, Chen X, Liu B, Zhu X, Wen J, You L et al.. (2016)
Comparison of the Superagonist Complex, ALT-803, to IL15 as Cancer Immunotherapeutics in Animal Models.
Cancer Immunol Res, 4 (1): 49-60. [PMID:26511282]
3. Zhu X, Marcus WD, Xu W, Lee HI, Han K, Egan JO, Yovandich JL, Rhode PR, Wong HC. (2009)
Novel human interleukin-15 agonists.
J. Immunol., 183 (6): 3598-607. [PMID:19710453]