Ligand id: 9615

Name: ALT-803

Structure and Physico-chemical Properties

2D Structure
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View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
ALT-803 promotes immune activation with anti-tumour activity against relapsed hematological malignancies in humans [1]. It has been shown to synergistically enhance the ADCC activity of therapeutic antibodies and anti-tumour activities of checkpoint inhibitors (anti-PD-1, anti-PD-L1 and anti-CTLA4 antibodies) in preclinical studies [2].
Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interleukin-15 receptor Hs Agonist Agonist ~12.3 pIC50 - 3
pIC50 ~12.3 (IC50 ~5x10-13 M) [3]
Description: Binding of rhIL-15N72D to hIL-15R in vitro.