- Advanced search
- Immuno Portal
- Malaria Portal
Synonyms: GSK-2256294 | GSK-2256294A | GSK2256294A
Compound class: Synthetic organic
Comment: GSK2256294 is an epoxide hydrolase 2 (sEH) inhibitor.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Blocher R, Lamers C, Wittmann SK, Diehl O, Hanke T, Merk D, Steinhilber D, Schubert-Zsilavecz M, Kahnt AS, Proschak E. (2016)
Design and synthesis of fused soluble epoxide hydrolase/peroxisome proliferator-activated receptor modulators.
Medchemcomm, 7: 1209-1216. DOI: 10.1039/C6MD00042H
2. Lazaar AL, Yang L, Boardley RL, Goyal NS, Robertson J, Baldwin SJ, Newby DE, Wilkinson IB, Tal-Singer R, Mayer RJ et al.. (2016)
Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor.
Br J Clin Pharmacol, 81 (5): 971-9. [PMID:26620151]
3. Spector AA, Fang X, Snyder GD, Weintraub NL. (2004)
Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
Prog. Lipid Res., 43 (1): 55-90. [PMID:14636671]
4. Spector AA, Norris AW. (2007)
Action of epoxyeicosatrienoic acids on cellular function.
Am. J. Physiol., Cell Physiol., 292 (3): C996-1012. [PMID:16987999]