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Synonyms: 7-Cl-O-Nec-1  | nec-1s | necrostatin 2 racemate
Compound class: Synthetic organic
Comment: Necrostatin-1s is a more stable analogue of necrostatin-1, that is more appropriate for in vivo investigations .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Berger SB, Harris P, Nagilla R, Kasparcova V, Hoffman S, Swift B, Dare L, Schaeffer M, Capriotti C, Ouellette M et al.. (2015)
Characterization of GSK'963: a structurally distinct, potent and selective inhibitor of RIP1 kinase.
Cell Death Discov, 1: 15009. [PMID:27551444]
2. Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S. (1998)
Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.
Proc Natl Acad Sci USA, 95 (19): 11211-6. [PMID:9736715]
3. Vandenabeele P, Grootjans S, Callewaert N, Takahashi N. (2013)
Necrostatin-1 blocks both RIPK1 and IDO: consequences for the study of cell death in experimental disease models.
Cell Death Differ, 20 (2): 185-7. [PMID:23197293]