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Synonyms: BMS 5 | BMS-5 | LIMKi 3
Compound class: Synthetic organic
Comment: Potent LIM kinase inhibitor.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Ross-Macdonald P, de Silva H, Guo Q, Xiao H, Hung CY, Penhallow B, Markwalder J, He L, Attar RM, Lin TA et al.. (2008)
Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors.
Mol Cancer Ther, 7 (11): 3490-8. [PMID:19001433]
2. Scott RW, Hooper S, Crighton D, Li A, König I, Munro J, Trivier E, Wickman G, Morin P, Croft DR et al.. (2010)
LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells.
J Cell Biol, 191 (1): 169-85. [PMID:20876278]
3. Sparrow N, Manetti ME, Bott M, Fabianac T, Petrilli A, Bates ML, Bunge MB, Lambert S, Fernandez-Valle C. (2012)
The actin-severing protein cofilin is downstream of neuregulin signaling and is essential for Schwann cell myelination.
J Neurosci, 32 (15): 5284-97. [PMID:22496574]
4. Yu Q, Gratzke C, Wang Y, Herlemann A, Sterr CM, Rutz B, Ciotkowska A, Wang X, Strittmatter F, Stief CG et al.. (2018)
Inhibition of human prostate smooth muscle contraction by the LIM kinase inhibitors, SR7826 and LIMKi3.
Br J Pharmacol, 175 (11): 2077-2096. [PMID:29574791]