CGP53353   Click here for help

GtoPdb Ligand ID: 5163

Synonyms: CGP 53353 | CGP-53353 | PKCbII/EGFR Inhibitor
Compound class: Synthetic organic
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 4
Topological polar surface area 70.23
Molecular weight 365.1
XLogP 3.74
No. Lipinski's rules broken 0
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Canonical SMILES Fc1ccc(cc1)Nc1cc2C(=O)NC(=O)c2cc1Nc1ccc(cc1)F
Isomeric SMILES Fc1ccc(cc1)Nc1cc2C(=O)NC(=O)c2cc1Nc1ccc(cc1)F
InChI InChI=1S/C20H13F2N3O2/c21-11-1-5-13(6-2-11)23-17-9-15-16(20(27)25-19(15)26)10-18(17)24-14-7-3-12(22)4-8-14/h1-10,23-24H,(H,25,26,27)

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen Click here for help
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

Reference: 1,3

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
protein kinase C beta PKCβII/PKCb2 Hs Inhibitor Inhibition 15.5 93.0 103.0
protein kinase C beta PKCβI/PKCb1 Hs Inhibitor Inhibition 28.2 107.0 86.0
mitogen-activated protein kinase 9 JNK2α2/JNK2 Hs Inhibitor Inhibition 61.4 112.0 84.0
STE20 like kinase nd/SLK(STK2) Hs Inhibitor Inhibition 65.5
EPH receptor A6 nd/EPHA6 Hs Inhibitor Inhibition 66.8
epidermal growth factor receptor EGFR/EGFR Hs Inhibitor Inhibition 70.7 25.0 6.0
calcium/calmodulin dependent protein kinase ID CaMKIδ/CAMK1d Hs Inhibitor Inhibition 78.1 112.0 89.0
zeta chain of T cell receptor associated protein kinase 70 ZAP-70/ZAP70 Hs Inhibitor Inhibition 78.8 113.0 119.0
serine/threonine kinase 10 LOK/LOK(STK10) Hs Inhibitor Inhibition 79.2 89.0 32.0
tyrosine kinase 2 nd/TYK2 Hs Inhibitor Inhibition 80.6
Displaying the top 10 targets  View all targets in screen »