motesanib

Ligand id: 5660

Name: motesanib

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 78.94
Molecular weight 373.19
XLogP 2.99
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Large-scale screening data

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1,3

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action Value Parameter
KIT proto-oncogene, receptor tyrosine kinase KIT(L576P) Hs Inhibitor Inhibition 8.9 pKd
KIT proto-oncogene, receptor tyrosine kinase KIT(V559D) Hs Inhibitor Inhibition 8.5 pKd
KIT proto-oncogene, receptor tyrosine kinase KIT Hs Inhibitor Inhibition 8.4 pKd
colony stimulating factor 1 receptor CSF1R Hs Inhibitor Inhibition 8.3 pKd
ZAK sterile alpha motif and leucine zipper containing kinase AZK ZAK Hs Inhibitor Inhibition 8.1 pKd
platelet derived growth factor receptor beta PDGFRB Hs Inhibitor Inhibition 8.0 pKd
fms related tyrosine kinase 4 FLT4 Hs Inhibitor Inhibition 8.0 pKd
platelet derived growth factor receptor alpha PDGFRA Hs Inhibitor Inhibition 8.0 pKd
fms related tyrosine kinase 1 FLT1 Hs Inhibitor Inhibition 7.9 pKd
KIT proto-oncogene, receptor tyrosine kinase KIT(V559D,T670I) Hs Inhibitor Inhibition 7.9 pKd
Displaying the top 10 targets  View all targets in screen »