motesanib

Ligand id: 5660

Name: motesanib

Structure and Physico-chemical Properties

2D Structure
Click here for structure editor
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 78.94
Molecular weight 373.19
XLogP 2.99
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Bioactivity Comments
Motesanib potently inhibits pro-angiogenic activity induced by VEGF receptor activation, and is equipotent at all three receptor isoforms [2]. Additionally this compound inhibits platelet-derived growth factor receptor, and stem cell factor receptor activity.
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
kinase insert domain receptor Hs Inhibitor Inhibition 8.6 pKd - 1
pKd 8.6 (Kd 2.6x10-9 M) [1]
fms related receptor tyrosine kinase 1 Hs Inhibitor Inhibition 8.7 pIC50 - 2
pIC50 8.7 (IC50 2x10-9 M) [2]
kinase insert domain receptor Hs Inhibitor Inhibition 8.5 pIC50 - 2
pIC50 8.5 (IC50 3x10-9 M) [2]
fms related receptor tyrosine kinase 4 Hs Inhibitor Inhibition 8.2 pIC50 - 2
pIC50 8.2 (IC50 6x10-9 M) [2]