MNK1 inhibitor   Click here for help

GtoPdb Ligand ID: 6010

Synonyms: CGP 57380 | CGP-57380
Compound class: Synthetic organic
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 92.51
Molecular weight 244.09
XLogP 2.03
No. Lipinski's rules broken 0
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Canonical SMILES Fc1ccc(cc1)Nc1[nH]nc2c1c(N)ncn2
Isomeric SMILES Fc1ccc(cc1)Nc1[nH]nc2c1c(N)ncn2
InChI InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen Click here for help
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

Reference: 1-2

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
AXL receptor tyrosine kinase Axl/AXL Hs Inhibitor Inhibition 45.4 90.0 57.0
EPH receptor A6 nd/EPHA6 Hs Inhibitor Inhibition 49.3
mitogen-activated protein kinase kinase kinase kinase 5 nd/KHS(MAP4K5) Hs Inhibitor Inhibition 52.0
mitogen-activated protein kinase kinase kinase kinase 4 nd/HGK(MAP4K4) Hs Inhibitor Inhibition 59.4
BR serine/threonine kinase 2 BrSK2/BRSK2 Hs Inhibitor Inhibition 60.6 65.0 12.0
tyrosine kinase non receptor 2 ACK1/ACK1 Hs Inhibitor Inhibition 61.5 60.0 17.0
BR serine/threonine kinase 1 BrSK1/BRSK1 Hs Inhibitor Inhibition 63.0 74.0 18.0
TXK tyrosine kinase Txk/TXK Hs Inhibitor Inhibition 67.6 66.0 18.0
casein kinase 1 delta CK1δ/CK1d Hs Inhibitor Inhibition 67.7 42.0 7.0
protein tyrosine kinase 6 BRK/BRK Hs Inhibitor Inhibition 68.3 51.0 19.0
Displaying the top 10 targets  View all targets in screen »