SKF-86002   Click here for help

GtoPdb Ligand ID: 6040

Synonyms: SK&F 86002 | SKF 86002
PDB Ligand
Compound class: Synthetic organic
Comment: SKF-86002 is a potent inhibitor of p38 MAPK.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 56.01
Molecular weight 297.07
XLogP 3.87
No. Lipinski's rules broken 0
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Canonical SMILES Fc1ccc(cc1)c1nc2n(c1c1ccncc1)CCS2
Isomeric SMILES Fc1ccc(cc1)c1nc2n(c1c1ccncc1)CCS2
InChI InChI=1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen Click here for help
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

Reference: 1-2

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
casein kinase 1 delta CK1δ/CK1d Hs Inhibitor Inhibition 7.0 3.0 1.0
casein kinase 1 epsilon nd/CK1epsilon Hs Inhibitor Inhibition 20.0
nemo like kinase NLK/NLK Hs Inhibitor Inhibition 41.1 52.0 20.0
mitogen-activated protein kinase 14 SAPK2a/P38a(MAPK14) Hs Inhibitor Inhibition 43.1 16.0 3.0
casein kinase 1 alpha 1 nd/CK1a1 Hs Inhibitor Inhibition 58.8
NIMA related kinase 11 NEK11/NEK11 Hs Inhibitor Inhibition 71.4 77.0 83.0
mitogen-activated protein kinase kinase kinase kinase 4 nd/HGK(MAP4K4) Hs Inhibitor Inhibition 72.3
EPH receptor A7 EphA7/EPHA7 Hs Inhibitor Inhibition 76.3 99.0 84.0
casein kinase 1 gamma 2 CK1γ2/CK1g2 Hs Inhibitor Inhibition 76.4 102.0 44.0
A-Raf proto-oncogene, serine/threonine kinase nd/ARAF Hs Inhibitor Inhibition 79.2
Displaying the top 10 targets  View all targets in screen »