VX-702   Click here for help

GtoPdb Ligand ID: 6059

Synonyms: I14-1965 | VX 702 | VX702
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: VX-702 is a third generation Investigational oral p38 MAP kinase Inhibitor [2].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 102.31
Molecular weight 404.09
XLogP 3.14
No. Lipinski's rules broken 0
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Canonical SMILES Fc1ccc(c(c1)F)c1nc(ccc1C(=O)N)N(c1c(F)cccc1F)C(=O)N
Isomeric SMILES Fc1ccc(c(c1)F)c1nc(ccc1C(=O)N)N(c1c(F)cccc1F)C(=O)N
InChI InChI=1S/C19H12F4N4O2/c20-9-4-5-10(14(23)8-9)16-11(18(24)28)6-7-15(26-16)27(19(25)29)17-12(21)2-1-3-13(17)22/h1-8H,(H2,24,28)(H2,25,29)

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen Click here for help
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.


Reference: 1,3

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
mitogen-activated protein kinase 14 SAPK2a/P38a(MAPK14) Hs Inhibitor Inhibition 5.2
nemo like kinase NLK/NLK Hs Inhibitor Inhibition 15.8
mitogen-activated protein kinase 11 SAPK2b/P38b(MAPK11) Hs Inhibitor Inhibition 22.3
platelet derived growth factor receptor beta PDGFRβ/PDGFRb Hs Inhibitor Inhibition 62.8
EPH receptor B3 EphB3/EPHB3 Hs Inhibitor Inhibition 65.8
NIMA related kinase 1 nd/NEK1 Hs Inhibitor Inhibition 69.6
megakaryocyte-associated tyrosine kinase nd/CTK(MATK) Hs Inhibitor Inhibition 77.6
EPH receptor A7 EphA7/EPHA7 Hs Inhibitor Inhibition 79.9
histone H3 associated protein kinase Haspin/Haspin Hs Inhibitor Inhibition 81.3
protein kinase D2 PKD2/PKD2(PRKD2) Hs Inhibitor Inhibition 81.8
Displaying the top 10 targets  View all targets in screen »