- Advanced search
- Immuno Portal
- Malaria Portal
Synonyms: sovesudil (proposed INN)
Compound class: Synthetic organic
Comment: Compound 18 is a Rho-associated, coiled coil containing protein kinase (ROCK) inhibitor from Amakem Therapeutics . It contains a carboxylic ester moiety that is intended to facilitate rapid inactivation by esterases in vivo, as a mechanism to reduce systemic or local ROCK-associated side effects. This approach of exploiting designed metabolic inactivation is used to produce so-called 'soft' drugs. Compound 18's chemical structure matches that submitted to the WHO for INN sovesudil. Compound 18 is intended as an intraocular pressure (IOP)-lowering agent, and is expected to be devoid of the systemic blood pressure lowering side effect that is associated with systemic exposure to fasudil and therefore precludes fasudil's use in non-cardiovascular indications . It is also expected to cause less local hyperemia than older ROCK inhibitor chemotypes. See our entry for compound 8 [PMID: 25898023], which is another soft ROCK inhibitor from Amakem Therapeutics.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖