clarithromycin   Click here for help

GtoPdb Ligand ID: 10903

Synonyms: 6-O-methylerythromycin | A-56268 | ABBOTT-56268 | Biaxin® | Klaricid® | TE-031
Approved drug PDB Ligand
clarithromycin is an approved drug (FDA (1991))
Compound class: Synthetic organic
Comment: Clarithromycin is a semisynthetic macrolide antibacterial. Structurally it is the 6-O-methyl ether of erythromycin A.
Click here for help

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

✖

View interactive charts of activity data across species
2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 14
Hydrogen bond donors 4
Rotatable bonds 8
Topological polar surface area 182.91
Molecular weight 747.48
XLogP 1.66
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

✖
Canonical SMILES CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@H]([C@@H](O2)C)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)OC
Isomeric SMILES CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@H]([C@@H](O2)C)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)OC
InChI InChI=1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
InChI Key AGOYDEPGAOXOCK-KCBOHYOISA-N

For advanced searching click here to open chemical structure editor

Similar Ligands Click here for help
alemcinal
Click here for ligand page
Targets
motilin receptor
EM-523
Click here for ligand page
Targets
motilin receptor
KOS1326
Click here for ligand page
Targets
motilin receptor
ME36
Click here for ligand page
Targets
motilin receptor
ME4
Click here for ligand page
Targets
motilin receptor
ME67
Click here for ligand page
Targets
motilin receptor
erythromycin
Click here for ligand page
Targets
OATP1B3; motilin receptor
roxithromycin
Click here for ligand page
Targets
motilin receptor
mitemcinal
Click here for ligand page
Targets
motilin receptor
azithromycin
Click here for ligand page
troleandomycin
Click here for ligand page
Targets
CYP3A4
maridomycin
Click here for ligand page
rosaramicin
Click here for ligand page
L-708365
Click here for ligand page
L-701677
Click here for ligand page
compound 2 [PMID: 33085774]
Click here for ligand page
Targets
null
idremcinal
Click here for ligand page
rokitamycin
Click here for ligand page
josamycin
Click here for ligand page
flurithromycin
Click here for ligand page
dirithromycin
Click here for ligand page
midecamycin
Click here for ligand page
oleandomycin
Click here for ligand page