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Synonyms: compound 32 [Specker et al., 2023] | TPT004
Compound class:
Synthetic organic
Comment: TPT-004 is a tryptophan hydroxylase (TPH) inhibitor [1]. When bound to the enzyme it occupies a domain across the pterin (cosubstrate) and tryptophan (substrate) binding sites. The compound is highly hydrophilic and is unable to cross the blood-brain barrier. TPT-004 is designed to inhibit TPH1 in the periphery whilst sparing the TPH2 isoform in the brain, to selectively target elevated serotonin levels in the periphery that are associated with pathological conditions (carcinoid syndrome, pulmonary arterial hypertension).
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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