AZD4877

Ligand id: 7708

Name: AZD4877

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 122.35
Molecular weight 503.24
XLogP 5.05
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

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Similar Ligands
[3H]DPCPX
Targets
A1 receptor; A2B receptor
LP-403812
Targets
PROT
SCH51866
Targets
phosphodiesterase 1A; phosphodiesterase 1B; phosphodiesterase 1C; phosphodiesterase 5A; phosphodiesterase 7B; phosphodiesterase 9A
edoxaban
Targets
coagulation factor X
acalabrutinib
Targets
BLK proto-oncogene, Src family tyrosine kinase; BMX non-receptor tyrosine kinase; Bruton tyrosine kinase; FYN proto-oncogene, Src family tyrosine kinase; IL2 inducible T cell kinase; Janus kinase 3; LCK proto-oncogene, Src family tyrosine kinase; LYN proto-oncogene, Src family tyrosine kinase; SRC proto-oncogene, non-receptor tyrosine kinase; TXK tyrosine kinase; epidermal growth factor receptor; erb-b2 receptor tyrosine kinase 2; erb-b2 receptor tyrosine kinase 4; tec protein tyrosine kinase
compound 3 [PMID: 26191365]
Targets
p21 (RAC1) activated kinase 1; p21 (RAC1) activated kinase 2
PKUMDL_MH_1001
Targets
15-LOX-1
upadacitinib
Targets
Janus kinase 1; Janus kinase 2; Janus kinase 3; tyrosine kinase 2
compound 36 [PMID: 21958547]
Targets
Bruton tyrosine kinase; LCK proto-oncogene, Src family tyrosine kinase; LYN proto-oncogene, Src family tyrosine kinase; SRC proto-oncogene, non-receptor tyrosine kinase
zanubrutinib
Targets
Bruton tyrosine kinase
theliatinib
Targets
LCK proto-oncogene, Src family tyrosine kinase; LYN proto-oncogene, Src family tyrosine kinase; YES proto-oncogene 1, Src family tyrosine kinase; epidermal growth factor receptor; erb-b2 receptor tyrosine kinase 4; tyrosine kinase non receptor 1
GNE-4997
Targets
IL2 inducible T cell kinase
TAK-931
Targets
cell division cycle 7