AM10257   Click here for help

GtoPdb Ligand ID: 10177

Synonyms: AM-10257
Compound class: Synthetic organic
Comment: AM10257 is a high affinity antagonist/inverse agonist of the cannabinoid CB2 receptor [1]. Low efficacy CB1 agonism has also been detected.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 67.15
Molecular weight 421.27
XLogP 5.3
No. Lipinski's rules broken 1
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Canonical SMILES OCCCCCn1nc(c(c1c1ccccc1)C)C(=O)NC12CC3CC(C2)CC(C1)C3
Isomeric SMILES OCCCCCn1nc(c(c1c1ccccc1)C)C(=O)NC12CC3CC(C2)CC(C1)C3
InChI InChI=1S/C26H35N3O2/c1-18-23(25(31)27-26-15-19-12-20(16-26)14-21(13-19)17-26)28-29(10-6-3-7-11-30)24(18)22-8-4-2-5-9-22/h2,4-5,8-9,19-21,30H,3,6-7,10-17H2,1H3,(H,27,31)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
Synonyms Click here for help
Database Links Click here for help
Specialist databases
GPCRdb Ligand AM10257
Other databases
GtoPdb PubChem SID 381118887
PubChem CID 137321161
Search Google for chemical match using the InChIKey FMJXYCCDMAGPLE-UHFFFAOYSA-N
Search Google for chemicals with the same backbone FMJXYCCDMAGPLE
UniChem Compound Search for chemical match using the InChIKey FMJXYCCDMAGPLE-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey FMJXYCCDMAGPLE-UHFFFAOYSA-N