indolmycin   Click here for help

GtoPdb Ligand ID: 11021

Synonyms: PA 155 A | PA-155-A | PA-155A | TAK-083
PDB Ligand Antimalarial Ligand
Compound class: Synthetic organic
Comment: Indolmycin competitively inhibits bacterial tryptophanyl-tRNA synthetases. It has antibacterial activity against MSSA (methicillin-susceptible Staphylococcus aureus), MRSA (methicillin-resistant S. aureus) and VISA (vancomycin-intermediate S. aureus) [2]. The compound also has antimalarial activity [3].

The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 66.48
Molecular weight 257.12
XLogP 1.96
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CN=C1NC(=O)[C@@H](O1)[C@@H](c1c[nH]c2c1cccc2)C
Isomeric SMILES CN=C1NC(=O)[C@@H](O1)[C@@H](c1c[nH]c2c1cccc2)C
InChI InChI=1S/C14H15N3O2/c1-8(12-13(18)17-14(15-2)19-12)10-7-16-11-6-4-3-5-9(10)11/h3-8,12,16H,1-2H3,(H,15,17,18)/t8-,12+/m1/s1
InChI Key GNTVWGDQPXCYBV-PELKAZGASA-N
Classification Click here for help
Compound class Synthetic organic
Ligand families/groups Antimalarial ligands
IUPAC Name Click here for help
(5S)-5-[(1R)-1-(1H-indol-3-yl)ethyl]-2-methylimino-1,3-oxazolidin-4-one
Synonyms Click here for help
PA 155 A | PA-155-A | PA-155A | TAK-083
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Indolmycin
Other databases
CAS Registry No. 21200-24-8 (source: ChemIDplus)
ChEBI CHEBI:79394
ChEMBL Ligand CHEMBL417852
GtoPdb PubChem SID 405560462
PubChem CID 135417159
RCSB PDB Ligand 5BX
Search Google for chemical match using the InChIKey GNTVWGDQPXCYBV-PELKAZGASA-N
Search Google for chemicals with the same backbone GNTVWGDQPXCYBV
UniChem Compound Search for chemical match using the InChIKey GNTVWGDQPXCYBV-PELKAZGASA-N
UniChem Connectivity Search for chemical match using the InChIKey GNTVWGDQPXCYBV-PELKAZGASA-N