imaradenant   Click here for help

GtoPdb Ligand ID: 11153

Synonyms: AZD-4635 | AZD4635
PDB Ligand Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: Imaradenant (AZD4635) is an orally bioavailable adenosine A2A receptor (A2AR) antagonist [2]. It was developed as a potential immuno-oncology (immunotherapy) drug. Imaradenant reduces the immunosuppressive effects of adenosine within the tumour microenvironment, an activity that rescues immune cell function and it enhances the efficacy of checkpoint inhibitors in syngeneic mouse tumour models [2].
In 2021 AstraZeneca decided to stop a number of their midphase studies of imaradenant in patients with prostate cancer.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 77.58
Molecular weight 315.07
XLogP 2.8
No. Lipinski's rules broken 0
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Canonical SMILES Nc1nnc(c(n1)c1ccc(cc1)F)c1cc(C)nc(c1)Cl
Isomeric SMILES Nc1nnc(c(n1)c1ccc(cc1)F)c1cc(C)nc(c1)Cl
InChI InChI=1S/C15H11ClFN5/c1-8-6-10(7-12(16)19-8)14-13(20-15(18)22-21-14)9-2-4-11(17)5-3-9/h2-7H,1H3,(H2,18,20,22)
Classification Click here for help
Compound class Synthetic organic
International Nonproprietary Names Click here for help
INN number INN
11244 imaradenant
Synonyms Click here for help
AZD-4635 | AZD4635
Database Links Click here for help
Specialist databases
GPCRdb Ligand imaradenant
Other databases
CAS Registry No. 1321514-06-0 (source: WHO INN record)
GtoPdb PubChem SID 434122213
PubChem CID 86676119
Search Google for chemical match using the InChIKey NCWQLHHDGDXIJN-UHFFFAOYSA-N
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UniChem Compound Search for chemical match using the InChIKey NCWQLHHDGDXIJN-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey NCWQLHHDGDXIJN-UHFFFAOYSA-N