camizestrant   Click here for help

GtoPdb Ligand ID: 12716

Synonyms: AZ-14066724 | AZ14066724 | AZD-9833 | AZD9833 | compound 28 PMID: 32910656]
Compound class: Synthetic organic
Comment: Camizestrant (AZD9833) is an orally available selective estrogen receptor degrader (SERD) [1] that was developed for antineoplastic potential in ER+ve breast cancers.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 55.26
Molecular weight 476.51
XLogP 2.68
No. Lipinski's rules broken 0
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Canonical SMILES C[C@@H]1CC2=C(C=CC3=C2C=NN3)[C@@H](C4=CC=C(C=N4)NC5CN(CCCF)C5)N1CC(F)(F)F
Isomeric SMILES FCCCN1CC(C1)NC=2C=CC(=NC2)[C@@H]3C4=CC=C5NN=CC5=C4C[C@H](N3CC(F)(F)F)C
InChI InChI=1S/C24H28F4N6/c1-15-9-19-18(4-6-21-20(19)11-30-32-21)23(34(15)14-24(26,27)28)22-5-3-16(10-29-22)31-17-12-33(13-17)8-2-7-25/h3-6,10-11,15,17,23,31H,2,7-9,12-14H2,1H3,(H,30,32)/t15-,23+/m1/s1
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
11592 camizestrant
Synonyms Click here for help
AZ-14066724 | AZ14066724 | AZD-9833 | AZD9833 | compound 28 PMID: 32910656]
Database Links Click here for help
CAS Registry No. 2222844-89-3 (source: WHO INN record)
ChEMBL Ligand CHEMBL4650365
GtoPdb PubChem SID 483123264
PubChem CID 134453496
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