(-)-noradrenaline   Click here for help

GtoPdb Ligand ID: 505

Synonyms: (-)-norepinephrine | Levarterenol® | noradrenaline
Approved drug PDB Ligand
(-)-noradrenaline is an approved drug (FDA (1950))
Compound class: Metabolite or derivative
Comment: Marketed formulations may contain noradrenaline tartrate (PubChem CID 25127519).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: noradrenaline

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 4
Rotatable bonds 2
Topological polar surface area 86.71
Molecular weight 169.07
XLogP -0.11
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES NCC(c1ccc(c(c1)O)O)O
Isomeric SMILES NC[C@@H](c1ccc(c(c1)O)O)O
InChI InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1
InChI Key SFLSHLFXELFNJZ-QMMMGPOBSA-N
Classification Click here for help
Compound class Metabolite or derivative
Approved drug? Yes (FDA (1950))
Prodrug droxidopa
IUPAC Name Click here for help
4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol
International Nonproprietary Names Click here for help
INN number INN
33 norepinephrine
Synonyms Click here for help
(-)-norepinephrine | Levarterenol® | noradrenaline
Database Links Click here for help
Specialist databases
GPCRdb Ligand (-)-noradrenaline
Other databases
BindingDB Ligand 50030618
CAS Registry No. 51-41-2 (source: Scifinder)
ChEMBL Ligand CHEMBL1437
DrugBank Ligand DB00368
DrugCentral Ligand 1960
GtoPdb PubChem SID 135651527
PubChem CID 439260
RCSB PDB Ligand LNR, LT4
Search Google for chemical match using the InChIKey SFLSHLFXELFNJZ-QMMMGPOBSA-N
Search Google for chemicals with the same backbone SFLSHLFXELFNJZ
Search PubMed clinical trials norepinephrine
Search PubMed titles norepinephrine
Search PubMed titles/abstracts norepinephrine
UniChem Compound Search for chemical match using the InChIKey SFLSHLFXELFNJZ-QMMMGPOBSA-N
UniChem Connectivity Search for chemical match using the InChIKey SFLSHLFXELFNJZ-QMMMGPOBSA-N
Wikipedia Norepinephrine