(±)-adrenaline   Click here for help

GtoPdb Ligand ID: 509

Synonyms: adrenaline | epinephrine
Compound class: Metabolite or derivative
Comment: The preparation of adrenaline/epinephrine assigned the INN racepinefrine is an racemic mixture of the enantiomers (+)-adrenaline and (-)-adrenaline. The structure shown here does not specify stereochemistry and represents the mixture.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 4
Rotatable bonds 3
Topological polar surface area 72.72
Molecular weight 183.09
XLogP 0.28
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CNCC(c1ccc(c(c1)O)O)O
Isomeric SMILES CNCC(c1ccc(c(c1)O)O)O
InChI InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3
InChI Key UCTWMZQNUQWSLP-UHFFFAOYSA-N
Classification Click here for help
Compound class Metabolite or derivative
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
Prodrug dipivefrine
IUPAC Name Click here for help
4-(1-hydroxy-2-methylaminoethyl)benzene-1,2-diol
International Nonproprietary Names Click here for help
INN number INN
4553 racepinefrine
Synonyms Click here for help
adrenaline | epinephrine
Database Links Click here for help
Specialist databases
GPCRdb Ligand (plusmn)-adrenaline
Other databases
BindingDB Ligand 50019058
CAS Registry No. 329-65-7 (source: Scifinder)
ChEBI CHEBI:33568
ChEMBL Ligand CHEMBL1740
DrugCentral Ligand 4508
GtoPdb PubChem SID 135651547
PubChem CID 838
Search Google for chemical match using the InChIKey UCTWMZQNUQWSLP-UHFFFAOYSA-N
Search Google for chemicals with the same backbone UCTWMZQNUQWSLP
Search PubMed clinical trials racepinefrine
Search PubMed titles racepinefrine
Search PubMed titles/abstracts racepinefrine
UniChem Compound Search for chemical match using the InChIKey UCTWMZQNUQWSLP-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey UCTWMZQNUQWSLP-UHFFFAOYSA-N
Wikipedia Epinephrine