orlistat   

GtoPdb Ligand ID: 5277

Synonyms: Alli® | tetrahydrolipstatin | THL | Xenical®
orlistat is an approved drug (FDA (1999), EMA (1998))
Compound class: Synthetic organic
Comment: Orlistat is a lipase inhibitor. Lipase targets include gastric and pancreatic lipases, diacylglycerol lipase (DAGL) and αβ-hydrolase 12 (ABHD12) inhibitor. It is used as an anti-obesity drug treatment. At least 18 isomeric forms exist in PubChem.
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: orlistat

2D Structure
Click here for structure editor
Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 24
Topological polar surface area 81.7
Molecular weight 495.39
XLogP 10.26
No. Lipinski's rules broken 2
SMILES / InChI / InChIKey
Canonical SMILES CCCCCCCCCCCC(CC1OC(=O)C1CCCCCC)OC(=O)C(CC(C)C)NC=O
Isomeric SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O
InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1
InChI Key AHLBNYSZXLDEJQ-FWEHEUNISA-N
Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1999), EMA (1998))
IUPAC Name
(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl (2S)-2-formamido-4-methylpentanoate
International Nonproprietary Names
INN number INN
6318 orlistat
Synonyms
Alli® | tetrahydrolipstatin | THL | Xenical®
Database Links
CAS Registry No. 96829-58-2 (source: PubChem)
ChEMBL Ligand CHEMBL175247
DrugBank Ligand DB01083
DrugCentral Ligand 1996
GtoPdb PubChem SID 178101960
PubChem CID 3034010
Search Google for chemical match using the InChIKey AHLBNYSZXLDEJQ-FWEHEUNISA-N
Search Google for chemicals with the same backbone AHLBNYSZXLDEJQ
Search PubMed clinical trials orlistat
Search PubMed titles orlistat
Search PubMed titles/abstracts orlistat
Search UniChem for chemical match using the InChIKey AHLBNYSZXLDEJQ-FWEHEUNISA-N
Search UniChem for chemicals with the same backbone AHLBNYSZXLDEJQ
Wikipedia Tetrahydrolipstatin

Product suppliers

View disclaimer

Tocris
Orlistat
Cat. No. 3540