warfarin   Click here for help

GtoPdb Ligand ID: 6853

Synonyms: Coumadin® | Marevan® | panwarfin
Approved drug
warfarin is an approved drug (FDA (1954))
Compound class: Synthetic organic
Comment: PubChem CID 54678486 is an enatiomeric mixture of the much more active S-form (CID 54688261) and the R-form (CID 54684598) [2]. This reference also reviews important pharmacogenomic aspects of this drug but note the application of this has become controversial (see the PharmKB drug link). Note also there is also a tautomeric variant depicted as CID 54689812. Marketed formulations may specify warfarin sodium (CID 16204922) or warfarin potassium (CID 23706212).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: warfarin

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 67.51
Molecular weight 308.1
XLogP 3.6
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CC(=O)CC(c1c(=O)oc2c(c1O)cccc2)c1ccccc1
Isomeric SMILES CC(=O)CC(c1c(=O)oc2c(c1O)cccc2)c1ccccc1
InChI InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3
InChI Key PJVWKTKQMONHTI-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1954))
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
IUPAC Name Click here for help
4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one
International Nonproprietary Names Click here for help
INN number INN
341 warfarin
Synonyms Click here for help
Coumadin® | Marevan® | panwarfin
Database Links Click here for help
Specialist databases
Reactome Drug Reactome logo R-ALL-9014945
Reactome Reaction Reactome logo R-HSA-9026967
Other databases
CAS Registry No. 81-81-2
ChEMBL Ligand CHEMBL1464
DrugBank Ligand DB00682
DrugCentral Ligand 2847
GtoPdb PubChem SID 178103459
Immunopaedia Search warfarin
PubChem CID 54678486
Search Google for chemical match using the InChIKey PJVWKTKQMONHTI-UHFFFAOYSA-N
Search Google for chemicals with the same backbone PJVWKTKQMONHTI
Search PubMed clinical trials warfarin
Search PubMed titles warfarin
Search PubMed titles/abstracts warfarin
UniChem Compound Search for chemical match using the InChIKey PJVWKTKQMONHTI-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey PJVWKTKQMONHTI-UHFFFAOYSA-N
Wikipedia Warfarin