alvimopan   Click here for help

GtoPdb Ligand ID: 7471

Synonyms: ADL 8-2698 | Entereg®
Approved drug
alvimopan is an approved drug (FDA (2008))
Compound class: Synthetic organic
Comment: Alvimopan is a peripherally acting mu-opioid receptor antagonist , or PAMORA.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 9
Topological polar surface area 89.87
Molecular weight 424.24
XLogP 3.06
No. Lipinski's rules broken 0
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Canonical SMILES OC(=O)CNC(=O)C(Cc1ccccc1)CN1CCC(C(C1)C)(C)c1cccc(c1)O
Isomeric SMILES OC(=O)CNC(=O)[C@@H](Cc1ccccc1)CN1CC[C@@]([C@H](C1)C)(C)c1cccc(c1)O
InChI InChI=1S/C25H32N2O4/c1-18-16-27(12-11-25(18,2)21-9-6-10-22(28)14-21)17-20(24(31)26-15-23(29)30)13-19-7-4-3-5-8-19/h3-10,14,18,20,28H,11-13,15-17H2,1-2H3,(H,26,31)(H,29,30)/t18-,20-,25+/m0/s1
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (2008))
IUPAC Name Click here for help
2-[[(2S)-2-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl]-3-phenylpropanoyl]amino]acetic acid
International Nonproprietary Names Click here for help
INN number INN
8245 alvimopan
Synonyms Click here for help
ADL 8-2698 | Entereg®
Database Links Click here for help
CAS Registry No. 156053-89-3
ChEMBL Ligand CHEMBL270190
DrugBank Ligand DB06274
DrugCentral Ligand 143
GtoPdb PubChem SID 187051774
PubChem CID 5488548
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Wikipedia Alvimopan