efgartigimod alfa   

GtoPdb Ligand ID: 9777

Synonyms: ARGX-113
Compound class: Antibody
Comment: Efgartigimod alfa (ARGX-113) is a first-in-class antibody fragment designed for the treatment of patients with severe autoimmune diseases associated with high levels of pathogenic immunoglobulin G (IgG) autoantibodies [6]. It binds to the IgG receptor, major histocompatibility complex class I-like Fc receptor (FcRn, the protein product of the FCGRT gene). Efgartigimod alfa inactivates FcRn's IgG binding ability (the FcRn-IgG interaction normally protects IgG from degradation) thus facilitating accelerated catabolism of native pathogenic autoantibodies [3,5]. The mechanism of this drug action is discussed more comprehensively in Roopenian and Akilesh (2007) [4] and Vaccaro et al. (2005) [7].
Compound class Antibody
International Nonproprietary Names
INN number INN
10455 efgartigimod alfa
Database Links
Specialist databases
IMGT/mAb-DB 731
Other databases
GtoPdb PubChem SID 354702250
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