Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	482	11q13.2	RPS6KB2	ribosomal protein S6 kinase B2
Mouse	-	485	19 A	Rps6kb2	ribosomal protein S6 kinase, polypeptide 2
Rat	-	485	1q42	Rps6kb2	ribosomal protein S6 kinase B2

Previous and Unofficial Names

S6Kβ2 | ribosomal protein S6 kinase, 70kD, polypeptide 2 | ribosomal protein S6 kinase beta-2 | S6K2 | KLS | STK14B | ribosomal protein S6 kinase

Database Links
Alphafold	Q9UBS0 (Hs), Q9Z1M4 (Mm)
BRENDA	2.7.11.1
ChEMBL Target	CHEMBL3111 (Hs)
Ensembl Gene	ENSG00000175634 (Hs), ENSMUSG00000024830 (Mm), ENSRNOG00000021689 (Rn)
Entrez Gene	6199 (Hs), 58988 (Mm), 361696 (Rn)
Human Protein Atlas	ENSG00000175634 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:6199 (Hs), mmu:58988 (Mm), rno:361696 (Rn)
OMIM	608939 (Hs)
Pharos	Q9UBS0 (Hs)
RefSeq Nucleotide	NM_003952 (Hs), NM_021485 (Mm), NM_001010962 (Rn)
RefSeq Protein	NP_003943 (Hs), NP_067460 (Mm), NP_001010962 (Rn)
UniProtKB	Q9UBS0 (Hs), Q9Z1M4 (Mm)
Wikipedia	RPS6KB2 (Hs)

Enzyme Reaction
EC Number: 2.7.11.1

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: ...1
Key to terms and symbols		Click column headers to sort
Target used in screen: nd/p70S6Kb(RPS6KB2)
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM staurosporine Hs Inhibitor Inhibition 4.7 Gö 6976 Hs Inhibitor Inhibition 21.6 K-252a Hs Inhibitor Inhibition 34.9 SB 218078 Hs Inhibitor Inhibition 35.0 midostaurin Hs Inhibitor Inhibition 55.9 GF109203X Hs Inhibitor Inhibition 59.0 Gö 6983 Hs Inhibitor Inhibition 65.4 Ro-32-0432 Hs Inhibitor Inhibition 67.6 H-89 Hs Inhibitor Inhibition 71.9 isogranulatimide Hs Inhibitor Inhibition 74.7
Displaying the top 10 most potent ligands  View all ligands in screen »