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ribosomal protein S6 kinase B2

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Target not currently curated in GtoImmuPdb

Target id: 1526

Nomenclature: ribosomal protein S6 kinase B2

Abbreviated Name: p70S6Kβ

Family: p70 subfamily

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 482 11q13.2 RPS6KB2 ribosomal protein S6 kinase B2
Mouse - 485 19 A Rps6kb2 ribosomal protein S6 kinase, polypeptide 2
Rat - 485 1q42 Rps6kb2 ribosomal protein S6 kinase B2
Previous and Unofficial Names Click here for help
S6Kβ2 | ribosomal protein S6 kinase, 70kD, polypeptide 2 | ribosomal protein S6 kinase beta-2 | S6K2 | KLS | STK14B | ribosomal protein S6 kinase
Database Links Click here for help
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 2.7.11.1
EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen Click here for help
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: ...1

Key to terms and symbols Click column headers to sort
Target used in screen: nd/p70S6Kb(RPS6KB2)
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 4.7
Gö 6976 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 21.6
K-252a Small molecule or natural product Hs Inhibitor Inhibition 34.9
SB 218078 Small molecule or natural product Hs Inhibitor Inhibition 35.0
midostaurin Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 55.9
GF109203X Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 59.0
Gö 6983 Small molecule or natural product Hs Inhibitor Inhibition 65.4
Ro-32-0432 Small molecule or natural product Hs Inhibitor Inhibition 67.6
H-89 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 71.9
isogranulatimide Small molecule or natural product Hs Inhibitor Inhibition 74.7
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1039-45. [PMID:22037377]

How to cite this page

p70 subfamily: ribosomal protein S6 kinase B2. Last modified on 25/07/2019. Accessed on 28/11/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1526.