Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	288	3q13.33	CD80	CD80 molecule
Mouse	1	306	16 26.86 cM	Cd80	CD80 antigen
Rat	-	321	11q21	Cd80	Cd80 molecule

Previous and Unofficial Names

B-lymphocyte activation antigen B7 | CD28LG | CD80 antigen

Database Links
Alphafold	P33681 (Hs), Q00609 (Mm)
CATH/Gene3D	2.60.40.10
ChEMBL Target	CHEMBL2364157 (Hs)
DrugBank Target	P33681 (Hs)
Ensembl Gene	ENSG00000121594 (Hs), ENSMUSG00000075122 (Mm), ENSRNOG00000001527 (Rn)
Entrez Gene	941 (Hs), 12519 (Mm), 25408 (Rn)
Human Protein Atlas	ENSG00000121594 (Hs)
KEGG Gene	hsa:941 (Hs), mmu:12519 (Mm), rno:25408 (Rn)
OMIM	112203 (Hs)
Pharos	P33681 (Hs)
RefSeq Nucleotide	NM_005191 (Hs), NM_009855 (Mm), NM_012926 (Rn)
RefSeq Protein	NP_005182 (Hs), NP_033985 (Mm), NP_037058 (Rn)
UniProtKB	P33681 (Hs), Q00609 (Mm)
Wikipedia	CD80 (Hs)

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference abatacept Hs Inhibition ~7.9 pKd 2-3 ⤷ pKd ~7.9 (Kd ~1.2x10-8 M) [2-3] Description: Measuring binding of 125I-labeled B7Ig fusion protein to immobilized abatacept. belatacept Hs Inhibition - - 1 ⤷ [1] Description: IC50= 0.009µg/mL

Immunopharmacology Comments

CD80 (B7-1) is expressed on dendritic cells and activated B cells and monocytes. It is required to provide a costimulatory signal necessary for T cell activation and survival. CD80 works in concert with CD86 to prime T cells. CD80 binds CD28 and CTLA-4 on T cells. It is the interaction with CTLA-4 that is targeted by the approved immunosuppresive drugs abatacept and belatacept.

Cell Type Associations

Immuno Cell Type:  Macrophages & monocytes Cell Ontology Term:   macrophage (CL:0000235) monocyte (CL:0000576)

Immuno Cell Type:  Dendritic cells Cell Ontology Term:   dendritic cell (CL:0000451)

Immuno Cell Type:  B cells Cell Ontology Term:   B cell (CL:0000236)

Immuno Cell Type:  T cells

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 1 GO processes GO:0045627 positive regulation of T-helper 1 cell differentiation NAS

Immuno Process:  T cell (activation) GO Annotations:  Associated to 5 GO processes GO:0031295 T cell costimulation IBA GO:0042102 positive regulation of T cell proliferation IBA GO:0042130 negative regulation of T cell proliferation IBA GO:0045627 positive regulation of T-helper 1 cell differentiation NAS GO:0046641 positive regulation of alpha-beta T cell proliferation IDA

Immuno Process:  B cell (activation) GO Annotations:  Associated to 1 GO processes GO:0045627 positive regulation of T-helper 1 cell differentiation NAS

Immuno Process:  Immune regulation GO Annotations:  Associated to 5 GO processes GO:0031295 T cell costimulation IBA GO:0042102 positive regulation of T cell proliferation IBA GO:0042130 negative regulation of T cell proliferation IBA GO:0045627 positive regulation of T-helper 1 cell differentiation NAS GO:0046641 positive regulation of alpha-beta T cell proliferation IDA

Immuno Process:  Immune system development GO Annotations:  Associated to 1 GO processes GO:0045627 positive regulation of T-helper 1 cell differentiation NAS

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 3 GO processes GO:0019221 cytokine-mediated signaling pathway TAS GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production NAS GO:0032743 positive regulation of interleukin-2 production NAS

Immuno Process:  Chemotaxis & migration GO Annotations:  Associated to 5 GO processes GO:0031295 T cell costimulation IBA GO:0042102 positive regulation of T cell proliferation IBA GO:0042130 negative regulation of T cell proliferation IBA GO:0045627 positive regulation of T-helper 1 cell differentiation NAS GO:0046641 positive regulation of alpha-beta T cell proliferation IDA

Immuno Process:  Cellular signalling GO Annotations:  Associated to 5 GO processes GO:0031295 T cell costimulation IBA GO:0042102 positive regulation of T cell proliferation IBA GO:0042130 negative regulation of T cell proliferation IBA GO:0045627 positive regulation of T-helper 1 cell differentiation NAS GO:0046641 positive regulation of alpha-beta T cell proliferation IDA

Immuno Process:  Barrier integrity GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:0001618 virus receptor activity IEA

Immuno Disease Associations

Disease Name:  Allograft rejection Disease Synonyms:  no synonynms Comment:  CD80 is a primary target of the approved anti-rejection drug belatacept.

Disease Name:  Rheumatoid arthritis Disease Synonyms:  no synonynms Comment:  CD80 is a primary target of the ligand abatacept, which is clinically approved for the treatment of rheumatoid arthritis. Disease X-refs:  Disease Ontology: DOID:7148 OMIM: 180300 References:  3

General Comments
This protein contains an immunoglobulin (Ig)-like domain that resembles the antibody variable domain, that has been coined the 'V-set domain'. The genes for all human V-set domain containing proteins are listed in HGNC gene group 590.