Top ▲

C-type lectin domain family 4 member C

Click here for help

Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 3135

Nomenclature: C-type lectin domain family 4 member C

Abbreviated Name: BDCA2

Family: C-type lectin-like receptors (CLRs)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 213 12p13.31 CLEC4C C-type lectin domain family 4 member C
Mouse 1 209 6 F2 Clec4b1 C-type lectin domain family 4, member b1
Rat 1 208 4q42 Clec4b2 C-type lectin domain family 4, member B2
Previous and Unofficial Names Click here for help
C-type lectin domain family 4, member B2 | C-type lectin domain family 4, member b1 | BDCA2 | Blood dendritic cell antigen 2 | CD303 | Dendritic lectin | DLEC | BDCA-2
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file go icon to follow link

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
BIIB059 Peptide Immunopharmacology Ligand Hs Binding - - 2
[2]
Immunopharmacology Comments
CLEC4C (BDCA2) is a type 2 transmembrane protein that is selectively expressed by plasmacytoid dendritic cells (pDCs). Like other C-type lectins, this membrane protein has roles in inflammation and immune responses. It is reported to capture non-sialylated galactose-terminated complex glycan antigens [4] and present them to T cells [1]. Ligand binding to CLEC4C inhibits induction of interferon (IFN) α/β production in pDCs. Since pDC-derived IFN α/β is considered to be a major pathophysiological driver in systemic lupus erythematosus (SLE), CLEC4C is being investigated as molecular target for the treatment of autoimmune lupus diseases, both SLE and the cutaneous form [2].
Cell Type Associations
Immuno Cell Type:  Dendritic cells
Cell Ontology Term:   plasmacytoid dendritic cell (CL:0000784)
References:  3
General Comments
CLEC4C is an immunoreceptor that expressed exclusively by plasmacytoid dendritic cells (pDCs).

References

Show »

1. Dzionek A, Sohma Y, Nagafune J, Cella M, Colonna M, Facchetti F, Günther G, Johnston I, Lanzavecchia A, Nagasaka T et al.. (2001) BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction. J. Exp. Med., 194 (12): 1823-34. [PMID:11748283]

2. Furie R, Werth VP, Merola JF, Stevenson L, Reynolds TL, Naik H, Wang W, Christmann R, Gardet A, Pellerin A et al.. (2019) Monoclonal antibody targeting BDCA2 ameliorates skin lesions in systemic lupus erythematosus. J. Clin. Invest., 129 (3): 1359-1371. [PMID:30645203]

3. Murray L, Xi Y, Upham JW. (2019) CLEC4C gene expression can be used to quantify circulating plasmacytoid dendritic cells. J. Immunol. Methods, 464: 126-130. [PMID:30395816]

4. Riboldi E, Daniele R, Parola C, Inforzato A, Arnold PL, Bosisio D, Fremont DH, Bastone A, Colonna M, Sozzani S. (2011) Human C-type lectin domain family 4, member C (CLEC4C/BDCA-2/CD303) is a receptor for asialo-galactosyl-oligosaccharides. J. Biol. Chem., 286 (41): 35329-33. [PMID:21880719]

How to cite this page

C-type lectin-like receptors (CLRs): C-type lectin domain family 4 member C. Last modified on 16/07/2020. Accessed on 21/10/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3135.