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ACKR2

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 314

Nomenclature: ACKR2

Family: Chemokine receptors

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor: Non-signalling 7TM chemokine-binding protein
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 384 3p22.1 ACKR2 atypical chemokine receptor 2
Mouse 7 378 9 F4 Ackr2 atypical chemokine receptor 2
Rat 7 382 8q32 Ackr2 atypical chemokine receptor 2
Previous and Unofficial Names Click here for help
CCR10 | CCR9 | CMBRK9 | C-C chemokine receptor D6 | chemokine binding protein 2 | CMKBR9
Database Links Click here for help
Specialist databases
GPCRdb ackr2_human (Hs), ackr2_mouse (Mm), ackr2_rat (Rn)
Other databases
Alphafold O00590 (Hs), O08707 (Mm), O09027 (Rn)
ChEMBL Target CHEMBL4105988 (Hs)
Ensembl Gene ENSG00000144648 (Hs), ENSMUSG00000044534 (Mm), ENSRNOG00000019472 (Rn)
Entrez Gene 1238 (Hs), 59289 (Mm), 140473 (Rn)
Human Protein Atlas ENSG00000144648 (Hs)
KEGG Gene hsa:1238 (Hs), mmu:59289 (Mm), rno:140473 (Rn)
OMIM 602648 (Hs)
Pharos O00590 (Hs)
RefSeq Nucleotide NM_001296 (Hs), NM_021609 (Mm), NM_078621 (Rn)
RefSeq Protein NP_001287 (Hs), NP_067622 (Mm), NP_511176 (Rn)
UniProtKB O00590 (Hs), O08707 (Mm), O09027 (Rn)
Wikipedia ACKR2 (Hs)
Endogenous agonists (Human)
CCL2 (CCL2, P13500), CCL3 (CCL3, P10147), CCL4 (CCL4, P13236), CCL5 (CCL5, P13501), CCL7 (CCL7, P80098), CCL8 (CCL8, P80075), CCL11 (CCL11, P51671), CCL13 (CCL13, Q99616), CCL14 (CCL14, Q16627), CCL17 (CCL17, Q92583), CCL22 (CCL22, O00626)
Immunopharmacology Comments
ACKR2 is one of more than 20 distinct chemokine receptors expressed in human leukocytes. Chemokines primarily act to promote leukocyte chemotaxis to sites of inflammation.
Immuno Process Associations
Immuno Process:  Antigen presentation
Immuno Process:  Cytokine production & signalling
Immuno Process:  Chemotaxis & migration
Immuno Process:  Inflammation
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Ccbp2tm1Gjg Ccbp2tm1Gjg/Ccbp2tm1Gjg
involves: 129/Sv * C57BL/6		 MGI:1891697  MP:0001194 dermatitis PMID: 15750596 
Ccbp2tm1Gjg Ccbp2tm1Gjg/Ccbp2tm1Gjg
involves: 129/Sv * C57BL/6		 MGI:1891697  MP:0001846 increased inflammatory response PMID: 15789340 

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